Bruce N. Ames 1988 Publications

207 Ames, B. N. and Saul, R. L. (1988) Cancer, Aging, and Oxidative DNA Damage. In: Theories of Carcinogenesis, O. H. Iversen, ed. (Hemisphere Publishing Corporation, New York, NY), pp. 203-220. check for PDF

208 Kramer, G. F. and Ames, B. N. (1988) Isolation and Characterization of a Selenium Metabolism Mutant in Salmonella typhimurium. J. Bacteriol. 170, 736-743. check for PDF

209 Adelman, R., Saul, R. L. and Ames, B. N. (1988) Oxidative Damage to DNA: Relation to Species Metabolic Rate and Life Span. Proc. Natl. Acad. Sci. USA 85, 2706-2708. check for PDF

210 Kohen, R., Yamamoto, Y., Cundy, K. C. and Ames, B. N. (1988) Antioxidant Activity of Carnosine, Homocarnosine, and Anserine Present in Muscle and Brain. Proc. Natl. Acad. Sci. USA 85, 3175-3179. check for PDF

211 Ames, B. N. and Gold, L. S. (1988) Carcinogenic Risk Estimation (Technical Comment). Science 240, 1045-1047. check for PDF

212 Baker, J. C. and Ames, B. N. (1988) Alterations in Levels of 5Ç-Adenyl Dinucleotides Following DNA Damage in Normal Human Fibroblasts and Fibroblasts Derived from Patients with Xeroderma Pigmentosum. Mutat. Res. 208, 87-93. check for PDF

213 Kramer, G. F., Baker, J. C. and Ames, B. N. (1988) Near-UV Stress in Salmonella typhimurium: 4-Thiouridine in tRNA, ppGpp, and ApppGpp as Components of an Adaptive Response. J. Bacteriol. 170, 2344-2351. check for PDF

214 Kramer, G. F. and Ames, B. N. (1988) Mechanisms of Mutagenicity and Toxicity of Sodium Selenite (Na2SeO3) in Salmonella typhimurium. Mutat. Res. 201, 169-180. check for PDF

215 Baker, J. C. and Ames, B. N. (1988) Alterations of NAD and Adenylyl Dinucleotide Metabolism in Chediak-Higashi Syndrome Fibroblasts. J. Inher. Metab. Dis. 11, 221-228. check for PDF

216 Richter, C., Park, J.-W. and Ames, B. N. (1988) Normal Oxidative Damage to Mitochondrial and Nuclear DNA is Extensive. Proc. Natl. Acad. Sci. USA 85, 6465-6467. check for PDF

217 Park, J.-W. and Ames, B. N. (1988) 7-Methylguanine Adducts in DNA are Normally Present at High Levels and Increase on Aging: Analysis by HPLC with Electrochemical Detection. Proc. Natl. Acad. Sci. USA 85, 7467-7470; Correction. Proc. Natl. Acad. Sci. USA 85, 9508. check for PDF

217a Blum, P. H. (1988) Reduced leu Operon Expression in a miaA Mutant of Salmonella typhimurium. J. Bacteriol. 170, 5125-5133. check for PDF

218 Frei, B., Yamamoto, Y., Niclas, D. and Ames, B. N. (1988) Evaluation of an Isoluminol Chemiluminescence Assay for the Detection of Hydroperoxides in Human Blood Plasma. Anal. Biochem. 175, 120-130. check for PDF

219 Frei, B., Stocker, R. and Ames, B. N. (1988) Antioxidant Defenses and Lipid Peroxidation in Human Blood Plasma. Proc. Natl. Acad. Sci. USA 85, 9748-9752. check for PDF

220 Ames, B. N. (1988) Measuring Oxidative Damage in Humans: Relation to Cancer and Ageing. In: Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention (IARC Scientific Publications No. 89), H. Bartsch, K. Hemminki and I. K. O'Neill, eds. (International Agency for Research on Cancer, Lyon, France), pp. 407-416. check for PDF

221 Frei, B., Yamamoto, Y., Niclas, D., Stocker, R., Cross, C. E. and Ames, B. N. (1988) Analysis of Oxidants and Antioxidants in Human Plasma of Healthy Subjects and of Patients with Adult Respiratory Distress Syndrome. In: Free Radicals, Methodology and Concepts, C. Rice-Evans and B. Halliwell, eds. (Richelieu, London, England), pp. 349-368. check for PDF

222 Cundy, K. C., Kohen, R. and Ames, B. N. (1988) Determination of 8-Hydroxydeoxyguanosine in Human Urine: A Possible Assay for in vivo Oxidative DNA Damage. In: Oxygen Radicals in Biology and Medicine, M. G. Simick, K. Taylor, J. F. Ward and C. von Sonntag, eds. (Plenum, New York, NY), pp. 479-482. check for PDF

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Contact Information

Mailing Address:
Children's Hospital Oakland Research Institute (CHORI),
5700 Martin Luther King Jr. Way, Oakland CA 94609.
Phone: (510) 450-7625
CHORI E-mail: bames@chori.org

Recent News

November 2008

October 2008

  • A new web graphic of Gold, Ames & Slone uses a Margin of Exposure index to provide a broad perspective on possible cancer hazards from human exposures to chemicals that cause cancer in high dose rodent tests. Exposures include high historical exposures to workers, pharmaceuticals, natural chemicals in the average diet (e.g., natural pesticides that plants produce to defend themselves), air pollutants, food additives, and pesticide residues. Human exposure levels range from close to the rodent carcinogenic dose for a few historical exposures in the workplace to a billion times less the rodent carcinogenic dose for some pesticide residues. Human consumption of the background of natural chemicals in food is usually closer to the rodent carcinogenic dose than pesticide residues or pollutants, and half the natural chemicals tested are carcinogenic in high dose tests. Recent risk assessment methods indicate that for some chemicals the mechanism of carcinogenesis in rodents at high dose is not relevant to humans.

June 2008

  • The CHORI webpage news article on Killilea & Ames magnesium Study:
    read article
  • Ames & Killilea News Study listed in 'AFAR Grantee's In the News' list
    go to AFAR site

April 2008

October 2007

For information on symposium proceedings and media please go to the Second Annual International Bruce Ames Symposium Website held at UC Davis.

Downloadable Media

The downloadable media section is constantly being updated. You will find that some links are not yet available. We apologize for the inconvenience and request that you come back periodically, to check for future availability.

Among the items available for download is a high resolution TIFF formated photograph of Dr. Ames (300 dpi resolution, and a 7MB ZIP archive), and Dr. Ames' streamed video lectures.

Dr. Ames' publications are also available by request to students and colleagues.
To request copies of Dr. Ames' publications, please fill out this electronic form.
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